Title: Generalized cohomology of pro-spectra Author: Daniel C. Isaksen E-mail: isaksen@math.wayne.edu AMS classification: 55T25, 55P42, 55U35, 55N20, 18G55 (Primary), 19L99 (Secondary) Abstract: We present a closed model structure for the category of pro-spectra in which the weak equivalences are detected by stable homotopy pro-groups. With some bounded-below assumptions, weak equivalences are also detected by cohomology as in the classical Whitehead theorem for spectra. We establish an Atiyah-Hirzebruch spectral sequence in this context, which makes possible the computation of topological K-theory (and other generalized cohomology theories) of pro-spectra.